Ontology highlight
ABSTRACT:
SUBMITTER: Fujita T
PROVIDER: S-EPMC3197142 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20111017 10
Comprehensive understanding of mechanisms of epigenetic regulation requires identification of molecules bound to genomic regions of interest in vivo. However, non-biased methods to identify molecules bound to specific genomic loci in vivo are limited. Here, we applied insertional chromatin immunoprecipitation (iChIP) to direct identification of components of insulator complexes, which function as boundaries of chromatin domain. We found that the chicken β-globin HS4 (cHS4) insulator complex cont ...[more]