Ontology highlight
ABSTRACT:
SUBMITTER: Liang J
PROVIDER: S-EPMC4198380 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Molecular cell 20140130 4
Eukaryotic chromosomes are partitioned into topologically associating domains (TADs) that are demarcated by distinct insulator-binding proteins (IBPs) in Drosophila. Whether IBPs regulate specific long-range contacts and how this may impact gene expression remains unclear. Here we identify "indirect peaks" of multiple IBPs that represent their distant sites of interactions through long-range contacts. Indirect peaks depend on protein-protein interactions among multiple IBPs and their common cofa ...[more]