Ontology highlight
ABSTRACT:
SUBMITTER: Carlsson J
PROVIDER: S-EPMC3197762 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Carlsson Jens J Coleman Ryan G RG Setola Vincent V Irwin John J JJ Fan Hao H Schlessinger Avner A Sali Andrej A Roth Bryan L BL Shoichet Brian K BK
Nature chemical biology 20110918 11
G protein-coupled receptors (GPCRs) are intensely studied as drug targets and for their role in signaling. With the determination of the first crystal structures, interest in structure-based ligand discovery increased. Unfortunately, for most GPCRs no experimental structures are available. The determination of the D(3) receptor structure and the challenge to the community to predict it enabled a fully prospective comparison of ligand discovery from a modeled structure versus that of the subseque ...[more]