Ontology highlight
ABSTRACT:
SUBMITTER: Levoin N
PROVIDER: S-EPMC4018084 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Levoin Nicolas N Calmels Thierry T Krief Stéphane S Danvy Denis D Berrebi-Bertrand Isabelle I Lecomte Jeanne-Marie JM Schwartz Jean-Charles JC Capet Marc M
ACS medicinal chemistry letters 20110211 4
Structure-based design methods commonly used in medicinal chemistry rely on a three-dimensional representation of the receptor. However, few crystal structures are solved in comparison with the huge number of pharmaceutical targets. This often renders homology models the only information available. It is particularly true for G protein-coupled receptors (GPCRs), one of the most important targets for approved medicines and current drug discovery projects. However, very few studies have tested the ...[more]