Ontology highlight
ABSTRACT:
SUBMITTER: Bhadra R
PROVIDER: S-EPMC3197960 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Bhadra Rajarshi R Gigley Jason P JP Khan Imtiaz A IA
Journal of immunology (Baltimore, Md. : 1950) 20110926 9
CD8 exhaustion mediated by an inhibitory programmed death-1-programmed death ligand-1 (PD-L1) pathway occurs in several chronic infections, including toxoplasmosis. Although blockade of the programmed death-1-PD-L1 pathway revives this response, the role of costimulatory receptors involved in this rescue has not been ascertained in any model of CD8 exhaustion. This report demonstrates that one such costimulatory pathway, CD40-CD40L, plays a critical role during rescue of exhausted CD8 T cells. B ...[more]