Ontology highlight
ABSTRACT:
SUBMITTER: Michalek RD
PROVIDER: S-EPMC3198034 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20110211 6
Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg require distinct metabolic programs to support these functions. Th1, Th2, and Th17 cells expressed high surface levels of the glucose transporter Glut1 and were highly glycolytic. Treg, in contrast, expressed low levels of Glut1 and had high lipid oxidation rates. Consistent with glycolysis and lipid oxidation pr ...[more]