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Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4+ T Cell Subsets.

ABSTRACT: The T follicular helper (Tfh) cell subset of CD4+ Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by analyzing the T cell-dependent B cell response to the protein Ag PE in mice lacking specific Th cell subsets. As expected, PE-specific germinal center B cell production required Tfh cells. However, Tfh, Th1, or Th17 cell-deficient mice produced as many PE-specific, isotype-switched plasmablasts as wild-type mice. This response depended on Th cell expression of CD154 and Ag presentation by B cells. These results indicate that many Th cell subsets can promote plasmablast formation by providing CD40 signals to naive B cells.

SUBMITTER: Kotov JA

PROVIDER: S-EPMC6324993 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Cutting Edge: T Cell-Dependent Plasmablasts Form in the Absence of Single Differentiated CD4<sup>+</sup> T Cell Subsets.

Kotov Jessica A JA Jenkins Marc K MK

Journal of immunology (Baltimore, Md. : 1950) 20181214 2

The T follicular helper (Tfh) cell subset of CD4<sup>+</sup> Th cells promotes affinity maturation by B cells in germinal centers. The contribution of other Th cell subsets to B cell responses has not been fully explored in vivo. We addressed this issue by analyzing the T cell-dependent B cell response to the protein Ag PE in mice lacking specific Th cell subsets. As expected, PE-specific germinal center B cell production required Tfh cells. However, Tfh, Th1, or Th17 cell-deficient mice produce ...[more]

PMID: 30552165

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