Ontology highlight
ABSTRACT:
SUBMITTER: Lang WH
PROVIDER: S-EPMC3198364 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Lang Walter H WH Coats Julie E JE Majka Jerzy J Hura Greg L GL Lin Yuyen Y Rasnik Ivan I McMurray Cynthia T CT
Proceedings of the National Academy of Sciences of the United States of America 20110929 42
Insertion and deletion of small heteroduplex loops are common mutations in DNA, but why some loops are prone to mutation and others are efficiently repaired is unknown. Here we report that the mismatch recognition complex, MSH2/MSH3, discriminates between a repair-competent and a repair-resistant loop by sensing the conformational dynamics of their junctions. MSH2/MSH3 binds, bends, and dissociates from repair-competent loops to signal downstream repair. Repair-resistant Cytosine-Adenine-Guanine ...[more]