Ontology highlight
ABSTRACT:
SUBMITTER: Tornier C
PROVIDER: S-EPMC1461642 | biostudies-other | 2001 May
REPOSITORIES: biostudies-other
Tornier C C Bessone S S Varlet I I Rudolph C C Darmon M M Fleck O O
Genetics 20010501 1
The msh6 mismatch repair gene of Schizosaccharomyces pombe was cloned, sequenced, and inactivated. Strains bearing all combinations of inactivated msh6, msh2, and swi4 (the S. pombe MSH3 ortholog) alleles were tested for their defects in mitotic and meiotic mismatch repair. Mitotic mutation rates were similarly increased in msh6 and msh2 mutants, both for reversion of a base-base substitution as well as of an insertion of one nucleotide in a mononucleotide run. Tetrad analysis and intragenic two ...[more]