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Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation.

ABSTRACT: Shortly after their discovery, repertoires of miRNA were identified, together with proteins involved in their biogenesis and action. It is now obvious that miRNA-mediated gene regulation itself is regulated at multiple levels. Identifying the regulatory mechanisms that underpin small RNA homeostasis by modulation of their biogenesis and action has become a key issue, which can be partly resolved by identifying mediators of Argonautes turnover. An emerging theme in the control of Argonaute stability and activity is through posttranslational modifications, which are the focus of this review.

SUBMITTER: Johnston M

PROVIDER: S-EPMC3199228 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Posttranslational modification of Argonautes and their role in small RNA-mediated gene regulation.

Johnston Michael M Hutvagner Gyorgy G

Silence 20110926

Shortly after their discovery, repertoires of miRNA were identified, together with proteins involved in their biogenesis and action. It is now obvious that miRNA-mediated gene regulation itself is regulated at multiple levels. Identifying the regulatory mechanisms that underpin small RNA homeostasis by modulation of their biogenesis and action has become a key issue, which can be partly resolved by identifying mediators of Argonautes turnover. An emerging theme in the control of Argonaute stabil ...[more]

PMID: 21943311

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