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MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes.

ABSTRACT: The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the reciprocal relationship-that of the cell cycle controlling the miR-16 family. Levels of this family increase rapidly as cells are arrested in G0. Conversely, as cells are released from G0 arrest, levels of the miR-16 family rapidly decrease. Such rapid changes are made possible by the unusual instabilities of several family members. The repression mediated by the miR-16 family is sensitive to these cell-cycle changes, which suggests that the rapid upregulation of the miR-16 family reinforces cell-cycle arrest in G0. Upon cell-cycle re-entry, the rapid decay of several members allows levels of the family to decrease, alleviating repression of target genes and allowing proper resumption of the cell cycle.

SUBMITTER: Rissland OS

PROVIDER: S-EPMC3202612 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes.

Rissland Olivia S OS Hong Sue-Jean SJ Bartel David P DP

Molecular cell 20110901 6

The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the reciprocal relationship-that of the cell cycle controlling the miR-16 family. Levels of this family increase rapidly as cells are arrested in G0. Conversely, as cells are released from G0 arrest, levels of the miR-16 family rapidly decrease. Such rapid changes are made possible ...[more]

PMID: 21925387

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