Ontology highlight
ABSTRACT:
SUBMITTER: Cilibrasi C
PROVIDER: S-EPMC6720056 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cilibrasi Chiara C Guzzi Andrèe A Bazzoni Riccardo R Riva Gabriele G Cadamuro Massimiliano M Hochegger Helfrid H Bentivegna Angela A
Journal of oncology 20190819
Glioma stem cells account for glioblastoma relapse and resistance to conventional therapies, and protein kinases, involved in the regulation of the mitotic machinery (i.e., Aurora kinases), have recently emerged as attractive therapeutic targets. In this study, we investigated the effect of Aurora kinases inhibition in five glioma stem cell lines isolated from glioblastoma patients. As expected, cell lines responded to the loss of Aurora kinases with cytokinesis failure and mitotic exit without ...[more]