Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC3205246 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Lu Zhenyu Z Ding Yuanqing Y Li Xing-Cong XC Djigbenou Daignon R DR Grimberg Brian T BT Ferreira Daneel D Ireland Chris M CM Van Wagoner Ryan M RM
Bioorganic & medicinal chemistry 20110601 22
A new fascaplysin analogue, 3-bromohomofascaplysin A (1), along with two known analogues, homofascaplysin A (2) and fascaplysin (3), were isolated from a Fijian Didemnum sp. ascidian. The absolute configurations of 3-bromohomofascaplysin A (1) and homofascaplysin A (2) were determined via experimental and theoretically calculated ECD spectra. The differential activities of 1-3 against different blood-borne life stages of the malaria pathogen Plasmodium falciparum were assessed. Homofascaplysin A ...[more]