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Hypervalent iodine(III)-induced methylene acetoxylation of 3-oxo-N-substituted butanamides.

ABSTRACT: 1-Carbamoyl-2-oxopropyl acetate derivatives were synthesized through an acetoxylation process to methylene with the aid of (diacetoxyiodo)benzene (DIB) as the oxidant. Not only mild reaction conditions, but also excellent yields and good substrate scope make the present protocol potentially useful in organic synthesis.

SUBMITTER: Liu WB

PROVIDER: S-EPMC3205772 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Hypervalent iodine(III)-induced methylene acetoxylation of 3-oxo-N-substituted butanamides.

Liu Wei-Bing WB Chen Cui C Zhang Qing Q Zhu Zhi-Bo ZB

Beilstein journal of organic chemistry 20111019

1-Carbamoyl-2-oxopropyl acetate derivatives were synthesized through an acetoxylation process to methylene with the aid of (diacetoxyiodo)benzene (DIB) as the oxidant. Not only mild reaction conditions, but also excellent yields and good substrate scope make the present protocol potentially useful in organic synthesis. ...[more]

PMID: 22049301

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