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Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk.


ABSTRACT:

Background

Presence of xenotropic murine leukemia virus-related virus and chronic inflammation in prostate tumor suggests that inflammation plays a role in prostate cancer etiology. This study investigated whether variants in inflammatory genes act alone or interact with plasma antioxidants to influence prostate cancer risk in a population-based case-control study in Central Arkansas.

Methods

Cases (n = 193) were men, aged 40-80, diagnosed with prostate cancer in three major hospitals in 1998-2003, and controls (n = 197) were matched to cases by age, race, and county of residence.

Results

After adjustment for confounders, polymorphisms in COX-2 (rs689466) and IL-8 (rs4073) were not significantly associated with prostate cancer risk. However, apparent interactions were observed between these genetic variants and plasma antioxidants on the risk of this malignancy. The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (>or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin]. Conversely, the promoting effect of the variant allele of the IL-8 polymorphism was more remarkable in subjects with low plasma levels of Lutein/zeaxanthin, beta-cryptoxanthin, and beta-carotene (ConclusionsWe found that sequence variants in inflammatory genes interact with plasma antioxidants to modulate prostate cancer risk.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC3207491 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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Publications

Polymorphisms in inflammatory genes, plasma antioxidants, and prostate cancer risk.

Zhang Jianjun J   Dhakal Ishwori B IB   Lang Nicholas P NP   Kadlubar Fred F FF  

Cancer causes & control : CCC 20100430 9


<h4>Background</h4>Presence of xenotropic murine leukemia virus-related virus and chronic inflammation in prostate tumor suggests that inflammation plays a role in prostate cancer etiology. This study investigated whether variants in inflammatory genes act alone or interact with plasma antioxidants to influence prostate cancer risk in a population-based case-control study in Central Arkansas.<h4>Methods</h4>Cases (n = 193) were men, aged 40-80, diagnosed with prostate cancer in three major hospi  ...[more]

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