Ontology highlight
ABSTRACT:
SUBMITTER: Landi S
PROVIDER: S-EPMC1634873 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Landi Stefano S Gemignani Federica F Bottari Fabio F Gioia-Patricola Lydie L Guino Elisabet E Cambray María M Biondo Sebastiano S Capella Gabriel G Boldrini Laura L Canzian Federico F Moreno Victor V
Journal of negative results in biomedicine 20061024
<h4>Background</h4>Chronic inflammation is a risk factor for colorectal cancer and polymorphisms in the inflammatory genes could modulate the levels of inflammation. We have investigated ten single nucleotide polymorphisms (SNPs) in the following inflammation-related genes: TLR4 (Asp299Gly), CD14 (-260 T>C), MCP1 (-2518 A>G), IL12A (+7506 A>T, +8707 A>G, +9177 T>A, +9508 G>A), NOS2A (+524T>C), TNF (-857C>T), and PTGS1 (V444I) in 377 colorectal (CRC) cancer cases and 326 controls from Barcelona ( ...[more]