A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
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ABSTRACT:
SUBMITTER: Qi HY
PROVIDER: S-EPMC3208068 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
Qi Hai-Yan HY Daniels Mathew P MP Liu Yueqin Y Chen Li-Yuan LY Alsaaty Sara S Levine Stewart J SJ Shelhamer James H JH
Journal of immunology (Baltimore, Md. : 1950) 20111014 10
Autophagy delivers cytoplasmic constituents to autophagosomes and is involved in innate and adaptive immunity. Cytosolic phospholipase (cPLA(2))-initiated proinflammatory lipid mediator pathways play a critical role in host defense and inflammation. The crosstalk between the two pathways remains unclear. In this study, we report that cPLA(2) and its metabolite lipid mediators induced autophagy in the RAW246.7 macrophage cell line and in primary monocytes. IFN-γ-triggered autophagy involves activ ...[more]
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