Ontology highlight
ABSTRACT:
SUBMITTER: Yaniv Y
PROVIDER: S-EPMC3208800 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Yaniv Yael Y Maltsev Victor A VA Escobar Ariel L AL Spurgeon Harold A HA Ziman Bruce D BD Stern Michael D MD Lakatta Edward G EG
Journal of molecular and cellular cardiology 20110914 6
Whether intracellular Ca(2+) regulates sinoatrial node cell (SANC) action potential (AP) firing rate on a beat-to-beat basis is controversial. To directly test the hypothesis of beat-to-beat intracellular Ca(2+) regulation of the rate and rhythm of SANC we loaded single isolated SANC with a caged Ca(2+) buffer, NP-EGTA, and simultaneously recorded membrane potential and intracellular Ca(2+). Prior to introduction of the caged Ca(2+) buffer, spontaneous local Ca(2+) releases (LCRs) during diastol ...[more]