Allostery modulates the beat rate of a cardiac pacemaker.
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ABSTRACT:
SUBMITTER: Tsai CJ
PROVIDER: S-EPMC5391769 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Allostery modulates the beat rate of a cardiac pacemaker.
Tsai Chung-Jung CJ Nussinov Ruth R
The Journal of biological chemistry 20170401 15
The S672R mutation in heart cell ion channels leads to low heart rates and arrhythmia by an unknown route. A multifaceted NMR analysis now demonstrates that this mutant impacts allosteric coupling in domains inside of the cell to change channel activation, providing a mechanistic explanation for phenotypic outcomes. ...[more]
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