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FOXA1: master of steroid receptor function in cancer.

ABSTRACT: FOXA transcription factors are potent, context-specific mediators of development that hold specialized functions in hormone-dependent tissues. Over the last several years, FOXA1 has emerged as a critical mediator of nuclear steroid receptor signalling, manifest at least in part through regulation of androgen receptor and oestrogen receptor activity. Recent findings point towards a major role for FOXA1 in modulating nuclear steroid receptor activity in breast and prostate cancer, and suggest that FOXA1 may significantly contribute to pro-tumourigenic phenotypes. The present review article will focus on the mechanisms, consequence, and clinical relevance of FOXA1-mediated steroid nuclear receptor signalling in human malignancy.

SUBMITTER: Augello MA

PROVIDER: S-EPMC3209791 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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FOXA1: master of steroid receptor function in cancer.

Augello Michael A MA Hickey Theresa E TE Knudsen Karen E KE

The EMBO journal 20110920 19

FOXA transcription factors are potent, context-specific mediators of development that hold specialized functions in hormone-dependent tissues. Over the last several years, FOXA1 has emerged as a critical mediator of nuclear steroid receptor signalling, manifest at least in part through regulation of androgen receptor and oestrogen receptor activity. Recent findings point towards a major role for FOXA1 in modulating nuclear steroid receptor activity in breast and prostate cancer, and suggest that ...[more]

PMID: 21934649

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