Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharyya S
PROVIDER: S-EPMC3210186 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Virology 20110819 1
Clathrin-mediated endocytosis was previously implicated as one of the cellular pathways involved in filoviral glycoprotein mediated viral entry into target cells. Here we have further dissected the requirements for different components of this pathway in Ebola versus Marburg virus glycoprotein (GP) mediated viral infection. Although a number of these components were involved in both cases; Ebola GP-dependent viral entry specifically required the cargo recognition proteins Eps15 and DAB2 as well ...[more]