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Enantioselective ?-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.


ABSTRACT: The enantioselective ?-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable ?-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

SUBMITTER: Harvey JS 

PROVIDER: S-EPMC3211083 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.

Harvey James S JS   Simonovich Scott P SP   Jamison Christopher R CR   MacMillan David W C DW  

Journal of the American Chemical Society 20110817 35


The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. ...[more]

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