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Enantioselective ?-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.

ABSTRACT: The enantioselective ?-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable ?-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

SUBMITTER: Harvey JS

PROVIDER: S-EPMC3211083 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.

Harvey James S JS Simonovich Scott P SP Jamison Christopher R CR MacMillan David W C DW

Journal of the American Chemical Society 20110817 35

The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. ...[more]

PMID: 21848265

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