Epigenetic regulation of miR-212 expression in lung cancer.
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ABSTRACT:
SUBMITTER: Incoronato M
PROVIDER: S-EPMC3216999 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Epigenetic regulation of miR-212 expression in lung cancer.
Incoronato Mariarosaria M Urso Loredana L Portela Ana A Laukkanen Mikko O MO Soini Ylermi Y Quintavalle Cristina C Keller Simona S Esteller Manel M Condorelli Gerolama G
PloS one 20111115 11
Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. M ...[more]
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