Ontology highlight
ABSTRACT:
SUBMITTER: Chen L
PROVIDER: S-EPMC3222380 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Chen Ling L Sham Caroline W CW Chan Ann M AM Francisco Loise M LM Wu Yin Y Mareninov Sergey S Sharpe Arlene H AH Freeman Gordon J GJ Yang Xian-Jie XJ Braun Jonathan J Gordon Lynn K LK
Investigative ophthalmology & visual science 20090506 10
<h4>Purpose</h4>Mammalian programmed cell death (PD)-1 is a membrane-associated receptor regulating the balance between T-cell activation, tolerance, and immunopathology; however, its role in neurons has not yet been defined. The hypothesis that PD-1 signaling actively promotes retinal ganglion cell (RGC) death within the developing mouse retina was investigated.<h4>Methods</h4>Mature retinal cell types expressing PD-1 were identified by immunofluorescence staining of vertical retina sections; d ...[more]