Ontology highlight
ABSTRACT:
SUBMITTER: Shen T
PROVIDER: S-EPMC3223071 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Shen Tao T Aneas Ivy I Sakabe Noboru N Dirschinger Ralf J RJ Wang Gang G Smemo Scott S Westlund John M JM Cheng Hongqiang H Dalton Nancy N Gu Yusu Y Boogerd Cornelis J CJ Cai Chen-leng CL Peterson Kirk K Chen Ju J Nobrega Marcelo A MA Evans Sylvia M SM
The Journal of clinical investigation 20111114 12
Human mutations in or variants of TBX20 are associated with congenital heart disease, cardiomyopathy, and arrhythmias. To investigate whether cardiac disease in patients with these conditions results from an embryonic or ongoing requirement for Tbx20 in myocardium, we ablated Tbx20 specifically in adult cardiomyocytes in mice. This ablation resulted in the onset of severe cardiomyopathy accompanied by arrhythmias, with death ensuing within 1 to 2 weeks of Tbx20 ablation. Accounting for this dram ...[more]