Ontology highlight
ABSTRACT:
SUBMITTER: Fu J
PROVIDER: S-EPMC3225978 | biostudies-literature | 2011 Jul-Aug
REPOSITORIES: biostudies-literature
Fu Jie J Hashem Yaser Y Wower Jacek J Frank Joachim J
RNA biology 20110701 4
Trans-translation is a universal quality-control process eubacteria use to degrade incompletely synthesized proteins and rescue ribosome stalled on defective mRNAs. This process is facilitated by a ribonucleoprotein complex composed of transfer-messenger RNA (tmRNA)-a chimera made of a tRNA-like molecule and a short open reading frame (ORF) -and small protein B (SmpB). Determination of the structure of tmRNA and SmpB in complex with the ribosome, at the stage when translation has resumed on tmRN ...[more]