Ontology highlight
ABSTRACT:
SUBMITTER: Thompson P
PROVIDER: S-EPMC3226931 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Thompson P P Badell I R IR Lowe M M Cano J J Song M M Leopardi F F Avila J J Ruhil R R Strobert E E Korbutt G G Rayat G G Rajotte R R Iwakoshi N N Larsen C P CP Kirk A D AD
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20110829 12
Significant deficiencies in understanding of xenospecific immunity have impeded the success of preclinical trials in xenoislet transplantation. Although galactose-α1,3-galactose, the gal epitope, has emerged as the principal target of rejection in pig-to-primate models of solid organ transplant, the importance of gal-specific immunity in islet xenotransplant models has yet to be clearly demonstrated. Here, we directly compare the immunogenicity, survival and function of neonatal porcine islets ( ...[more]