Ontology highlight
ABSTRACT:
SUBMITTER: Piskounova E
PROVIDER: S-EPMC3227872 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Piskounova Elena E Polytarchou Christos C Thornton James E JE LaPierre Robert J RJ Pothoulakis Charalabos C Hagan John P JP Iliopoulos Dimitrios D Gregory Richard I RI
Cell 20111101 5
Lin28A and Lin28B selectively block the expression of let-7 microRNAs and function as oncogenes in a variety of human cancers. Lin28A recruits a TUTase (Zcchc11/TUT4) to let-7 precursors to block processing by Dicer in the cell cytoplasm. Here we find that unlike Lin28A, Lin28B represses let-7 processing through a Zcchc11-independent mechanism. Lin28B functions in the nucleus by sequestering primary let-7 transcripts and inhibiting their processing by the Microprocessor. The inhibitory effects o ...[more]