Dataset Information

Three measures of forest fire smoke exposure and their associations with respiratory and cardiovascular health outcomes in a population-based cohort.

ABSTRACT:

Background

During the summer of 2003 numerous fires burned in British Columbia, Canada.

Objectives

We examined the associations between respiratory and cardiovascular physician visits and hospital admissions, and three measures of smoke exposure over a 92-day study period (1 July to 30 September 2003).

Methods

A population-based cohort of 281,711 residents was identified from administrative data. Spatially specific daily exposure estimates were assigned to each subject based on total measurements of particulate matter (PM) ? 10 ?m in aerodynamic diameter (PM10) from six regulatory tapered element oscillating microbalance (TEOM) air quality monitors, smoke-related PM10 from a CALPUFF dispersion model run for the study, and a SMOKE exposure metric for plumes visible in satellite images. Logistic regression with repeated measures was used to estimate associations with each outcome.

Results

The mean (± SD) exposure based on TEOM-measured PM10 was 29 ± 31 ?g/m3, with an interquartile range of 14-31 ?g/m3. Correlations between the TEOM, smoke, and CALPUFF metrics were moderate (0.37-0.76). Odds ratios (ORs) for a 30-?g/m3 increase in TEOM-based PM10 were 1.05 [95% confidence interval (CI), 1.03-1.06] for all respiratory physician visits, 1.16 (95% CI, 1.09-1.23) for asthma-specific visits, and 1.15 (95% CI, 1.00-1.29) for respiratory hospital admissions. Associations with cardiovascular outcomes were largely null.

Conclusions

Overall we found that increases in TEOM-measured PM10 were associated with increased odds of respiratory physician visits and hospital admissions, but not with cardiovascular health outcomes. Results indicating effects of fire smoke on respiratory outcomes are consistent with previous studies, as are the null results for cardiovascular outcomes. Some agreement between TEOM and the other metrics suggests that exposure assessment tools that are independent of air quality monitoring may be useful with further refinement.

SUBMITTER: Henderson SB

PROVIDER: S-EPMC3230386 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Publications

Three measures of forest fire smoke exposure and their associations with respiratory and cardiovascular health outcomes in a population-based cohort.

Henderson Sarah B SB Brauer Michael M Macnab Ying C YC Kennedy Susan M SM

Environmental health perspectives 20110609 9

<h4>Background</h4>During the summer of 2003 numerous fires burned in British Columbia, Canada.<h4>Objectives</h4>We examined the associations between respiratory and cardiovascular physician visits and hospital admissions, and three measures of smoke exposure over a 92-day study period (1 July to 30 September 2003).<h4>Methods</h4>A population-based cohort of 281,711 residents was identified from administrative data. Spatially specific daily exposure estimates were assigned to each subject base ...[more]

PMID: 21659039

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Project description:The association between cigarette smoke exposure and the acute respiratory distress syndrome in patients with the most common acute respiratory distress syndrome risk factors of sepsis, pneumonia, and aspiration has not been well studied. The goal of this study was to test the association between biomarker-confirmed cigarette smoking and acute respiratory distress syndrome in a diverse cohort.Prospective cohort.Tertiary care center.Four hundred twenty-six critically ill patients with acute respiratory distress syndrome risk factors (excluding trauma and transfusion): None.We obtained smoking histories and measured urine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanol (a biomarker of cigarette smoke exposure) on urine samples obtained at the time of study enrollment. The association between cigarette smoke exposure and acute respiratory distress syndrome differed based on acute respiratory distress syndrome risk factor (p < 0.02 for interaction). In patients with nonpulmonary sepsis as the primary acute respiratory distress syndrome risk factor (n = 212), 39% of those with acute respiratory distress syndrome were current smokers by history compared with 22% of those without acute respiratory distress syndrome (odds ratio, 2.28; 95% CI, 1.24-4.19; p = 0.008). Likewise, cigarette smoke exposure as measured by urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol was significantly associated with acute respiratory distress syndrome in this group. The increased risk of acute respiratory distress syndrome in nonpulmonary sepsis was restricted to patients with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels consistent with active smoking and was robust to adjustment for other acute respiratory distress syndrome predictors. Cigarette smoke exposure as measured by history or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol was not associated with acute respiratory distress syndrome in patients with other risk factors (e.g., pneumonia and aspiration).Cigarette smoking measured both by history and biomarker is associated with an increased risk of acute respiratory distress syndrome in patients with nonpulmonary sepsis. This finding has important implications for tobacco product regulation and for understanding the pathogenesis of acute respiratory distress syndrome.

Dataset Information

Three measures of forest fire smoke exposure and their associations with respiratory and cardiovascular health outcomes in a population-based cohort.

Background

Objectives

Methods

Results

Conclusions

Publications

Three measures of forest fire smoke exposure and their associations with respiratory and cardiovascular health outcomes in a population-based cohort.

Similar Datasets

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