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High-resolution NMR spectroscopy of a GPCR in aligned bicelles.

ABSTRACT: Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions.

SUBMITTER: Park SH

PROVIDER: S-EPMC3236030 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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High-resolution NMR spectroscopy of a GPCR in aligned bicelles.

Park Sang Ho SH Prytulla Stefan S De Angelis Anna A AA Brown Jonathan Miles JM Kiefer Hans H Opella Stanley J SJ

Journal of the American Chemical Society 20060601 23

Solid-state NMR spectra with single-site resolution of CXCR1, a G protein-coupled receptor (GPCR), were obtained in magnetically aligned phospholipid bicelles. These results demonstrate that GPCRs in phospholipid bilayers are suitable samples for structure determination by solid-state NMR. The spectra also enable studies of drug-receptor interactions. ...[more]

PMID: 16756269

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