Ontology highlight
ABSTRACT:
SUBMITTER: Park SH
PROVIDER: S-EPMC3236031 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Biochemistry 20110930 42
It is challenging to find membrane mimics that stabilize the native structures, dynamics, and functions of membrane proteins. In a recent advance, nanodiscs have been shown to provide a bilayer environment compatible with solution NMR. We show that increasing the lipid to "belt" peptide ratio expands their diameter, slows their reorientation rate, and allows the protein-containing discs to be aligned in a magnetic field for oriented sample solid-state NMR. The spectroscopic properties of membran ...[more]