The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, (99m)Tc) radiopharmaceuticals.
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ABSTRACT:
SUBMITTER: Ganguly T
PROVIDER: S-EPMC3236597 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
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The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, (99m)Tc) radiopharmaceuticals.
Ganguly Tanushree T Kasten Benjamin B BB Bučar Dejan-Krešimir DK MacGillivray Leonard R LR Berkman Clifford E CE Benny Paul D PD
Chemical communications (Cambridge, England) 20111101 48
Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, (99m)Tc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy. ...[more]
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