Ontology highlight
ABSTRACT:
SUBMITTER: Ye Y
PROVIDER: S-EPMC6076275 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Ye Yunpeng Y Toczek Jakub J Gona Kiran K Kim Hye-Yeong HY Han Jinah J Razavian Mahmoud M Golestani Reza R Zhang Jiasheng J Wu Terence L TL Ghosh Mousumi M Jung Jae-Joon JJ Sadeghi Mehran M MM
Scientific reports 20180803 1
Matrix metalloproteinases (MMPs) are involved in tissue remodeling. Accordingly, MMP inhibitors and related radiolabeled analogs are important tools for MMP-targeted imaging and therapy in a number of diseases. Herein, we report design, synthesis, and evaluation of a new Arginine-containing macrocyclic hydroxamate analog, RYM, its hydrazinonicotinamide conjugate, RYM1 and <sup>99m</sup>Tc-labeled analog <sup>99m</sup>Tc-RYM1 for molecular imaging. RYM exhibited potent inhibition against a panel ...[more]