Dataset Information

Cigarette smoking and p16INK4? gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis.

ABSTRACT:

Background

Aberrant methylation of promoter DNA and transcriptional repression of specific tumor suppressor genes play an important role in carcinogenesis. Recently, many studies have investigated the association between cigarette smoking and p16(INK4?) gene hypermethylation in lung cancer, but could not reach a unanimous conclusion.

Methods and findings

Nineteen cross-sectional studies on the association between cigarette smoking and p16(INK4?) methylation in surgically resected tumor tissues from non-small cell lung carcinoma (NSCLC) patients were identified in PubMed database until June 2011. For each study, a 2×2 cross-table was extracted. In total, 2,037 smoker and 765 nonsmoker patients were pooled with a fixed-effects model weighting for the inverse of the variance. Overall, the frequency of p16(INK4?) hypermethylation was higher in NSCLC patients with smoking habits than that in non-smoking patients (OR?=?2.25, 95% CI?=?1.81-2.80). The positive association between cigarette smoking and p16(INK4?) hypermethylation was similar in adenocarcinoma and squamous-cell carcinoma. In the stratified analyses, the association was stronger in Asian patients and in the studies with larger sample sizes.

Conclusion

Cigarette smoking is positively correlated to p16(INK4?) gene hypermethylation in NSCLC patients.

SUBMITTER: Zhang B

PROVIDER: S-EPMC3236763 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Publications

Cigarette smoking and p16INK4α gene promoter hypermethylation in non-small cell lung carcinoma patients: a meta-analysis.

Zhang Bo B Zhu Wei W Yang Ping P Liu Tao T Jiang Mei M He Zhi-Ni ZN Zhang Shi-Xin SX Chen Wei-Qing WQ Chen Wen W

PloS one 20111213 12

<h4>Background</h4>Aberrant methylation of promoter DNA and transcriptional repression of specific tumor suppressor genes play an important role in carcinogenesis. Recently, many studies have investigated the association between cigarette smoking and p16(INK4α) gene hypermethylation in lung cancer, but could not reach a unanimous conclusion.<h4>Methods and findings</h4>Nineteen cross-sectional studies on the association between cigarette smoking and p16(INK4α) methylation in surgically resected ...[more]

PMID: 22174919

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