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Gram-scale synthesis of the A'B'-subunit of angelmicin B.

ABSTRACT: A gram-scale enantiospecific synthesis of the A'B'-subunit of angelmicin B is reported. The synthesis involves a Lewis acid catalyzed contrasteric Diels-Alder reaction and a tandem silyl zincate 1,6-addition/enolate oxidation sequence.

SUBMITTER: Milgram BC

PROVIDER: S-EPMC3237735 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Gram-scale synthesis of the A'B'-subunit of angelmicin B.

Milgram Benjamin C BC Liau Brian B BB Shair Matthew D MD

Organic letters 20111115 24

A gram-scale enantiospecific synthesis of the A'B'-subunit of angelmicin B is reported. The synthesis involves a Lewis acid catalyzed contrasteric Diels-Alder reaction and a tandem silyl zincate 1,6-addition/enolate oxidation sequence. ...[more]

PMID: 22084899

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