Ontology highlight
ABSTRACT:
SUBMITTER: Hatakeyama S
PROVIDER: S-EPMC3241764 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Hatakeyama Shingo S Sugihara Kazuhiro K Shibata Toshiaki K TK Nakayama Jun J Akama Tomoya O TO Tamura Naoaki N Wong Shuk-Man SM Bobkov Andrey A AA Takano Yutaka Y Ohyama Chikara C Fukuda Minoru M Fukuda Michiko N MN
Proceedings of the National Academy of Sciences of the United States of America 20111123 49
Although numerous carbohydrates play significant roles in mammalian cells, carbohydrate-based drug discovery has not been explored due to the technical difficulty of chemically synthesizing complex carbohydrate structures. Previously, we identified a series of carbohydrate mimetic peptides and found that a 7-mer peptide, designated I-peptide, inhibits hematogenous carbohydrate-dependent cancer cell colonization. During analysis of the endothelial surface receptor for I-peptide, we found that I-p ...[more]