Ontology highlight
ABSTRACT:
SUBMITTER: Murphy EA
PROVIDER: S-EPMC2453735 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Murphy Eric A EA Majeti Bharat K BK Barnes Leo A LA Makale Milan M Weis Sara M SM Lutu-Fuga Kimberly K Wrasidlo Wolfgang W Cheresh David A DA
Proceedings of the National Academy of Sciences of the United States of America 20080707 27
Integrin alphanubeta3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an alphanubeta3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the alphanubeta3-expressing tumor vasculature. We observed real-time targeting of this NP to tumor vessels and noted selective apoptosis in regions of the alphanubeta3-expressing tumor vasculature. In clinically relevant pancreat ...[more]