Ontology highlight
ABSTRACT:
SUBMITTER: Georges E
PROVIDER: S-EPMC3242425 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Georges Elias E Bonneau Anne-Marie AM Prinos Panagiotis P
International journal of biochemistry and molecular biology 20111021 4
The over-expression of α-enolase was demonstrated in several cancers, including lung, brain, breast, colon and prostate. In this report, we investigated the effects of α-enolase knockdown on the sensitivity of cancer cells to chemotherapeutic drugs. RNAi-mediated knockdown of α-enolase in A549 and H460 lung, MCF7 breast and CaOV3 ovarian cancer cells caused a significant increase in the sensitivity of these cells to antitubulin chemotherapeutics (e.g., vincristine and taxol), but not to doxorubi ...[more]