Ontology highlight
ABSTRACT:
SUBMITTER: Di Paolo D
PROVIDER: S-EPMC3242652 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Di Paolo Daniela D Ambrogio Chiara C Pastorino Fabio F Brignole Chiara C Martinengo Cinzia C Carosio Roberta R Loi Monica M Pagnan Gabriella G Emionite Laura L Cilli Michele M Ribatti Domenico D Allen Theresa M TM Chiarle Roberto R Ponzoni Mirco M Perri Patrizia P
Molecular therapy : the journal of the American Society of Gene Therapy 20110809 12
The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB). In NB, ALK overexpression, or point mutations, are associated with poor prognosis and advanced stage disease. Inhibition of ALK kinase activity by small-molecule inhibitors in lung cancers carrying ALK translocations has shown therapeutic potential. However, secondary mutations may occur that, generate tumor resistance to ALK i ...[more]