Shifting from a gene-centric to metabolite-centric strategy to determine the core gut microbiome.
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ABSTRACT:
SUBMITTER: Marchesi JR
PROVIDER: S-EPMC3242787 | biostudies-literature | 2011 Nov-Dec
REPOSITORIES: biostudies-literature
Publications
Shifting from a gene-centric to metabolite-centric strategy to determine the core gut microbiome.
Bioengineered bugs 20111101 6
A key challenge in the area of determining how the microbiome communicates with the host's karyome is deciding which microbial functions should be studied. Ideally we would wish to look at functions which are not only important to the microbial host, but which also play roles in host physiology. Selecting the key microbial functions is essential to developing robust strategies to either promote or demote them, with the aim to enhancing host health. This commentary argues that the bottom-up appro ...[more]
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