Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification.
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ABSTRACT:
SUBMITTER: Kortholt A
PROVIDER: S-EPMC3245697 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Dictyostelium chemotaxis: essential Ras activation and accessory signalling pathways for amplification.
Kortholt Arjan A Kataria Rama R Keizer-Gunnink Ineke I Van Egmond Wouter N WN Khanna Ankita A Van Haastert Peter J M PJ
EMBO reports 20111201 12
Central to chemotaxis is the molecular mechanism by which cells exhibit directed movement in shallow gradients of a chemoattractant. We used Dictyostelium mutants to investigate the minimal requirements for chemotaxis, and identified a basal signalling module providing activation of Ras at the leading edge, which is sufficient for chemotaxis. The signalling enzymes PI3K, TorC2, PLA2 and sGC are not required for Ras activation and chemotaxis to folate or to steep gradients of cAMP, but they provi ...[more]
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