Ontology highlight
ABSTRACT:
SUBMITTER: Oliver JA
PROVIDER: S-EPMC3246089 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Oliver Jennifer A JA Stolberg Valerie R VR Chensue Stephen W SW King Philip D PD
Cytokine 20111109 1
CD8+ T cell synthesis of IFN-γ is an important component of the CD8+ T cell immune response. In short-term cultures of murine pan-T cells, we found that IL-4 was the principal cytokine responsible for driving IFN-γ synthesis by CD3/CD28-activated CD8+ T cells. IL-4 was able to induce low levels of IFN-γ mRNA in CD8+ T cells even in the absence of CD3/CD28 engagement, although concomitant CD3/CD28 stimulation was necessary for IFN-γ secretion. IL-4 induction of IFN-γ was explained by its ability ...[more]