Ontology highlight
ABSTRACT:
SUBMITTER: Intlekofer AM
PROVIDER: S-EPMC2807624 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Intlekofer Andrew M AM Banerjee Arnob A Takemoto Naofumi N Gordon Scott M SM Dejong Caitlin S CS Shin Haina H Hunter Christopher A CA Wherry E John EJ Lindsten Tullia T Reiner Steven L SL
Science (New York, N.Y.) 20080701 5887
When intracellular pathogens invade mammalian hosts, naïve CD8+ T cells differentiate into cytotoxic killers, which lyse infected target cells and secrete cytokines that activate intracellular microbicides. We show that CD8+ T cells deficient in the transcription factors T-bet and eomesodermin (Eomes) fail to differentiate into functional killers required for defense against lymphocytic choriomeningitis virus. Instead, virus-specific CD8+ T cells lacking both T-bet and Eomes differentiate into a ...[more]