Ontology highlight
ABSTRACT:
SUBMITTER: Hitosugi T
PROVIDER: S-EPMC3246218 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Hitosugi Taro T Fan Jun J Chung Tae-Wook TW Lythgoe Katherine K Wang Xu X Xie Jianxin J Ge Qingyuan Q Gu Ting-Lei TL Polakiewicz Roberto D RD Roesel Johannes L JL Chen Georgia Z GZ Boggon Titus J TJ Lonial Sagar S Fu Haian H Khuri Fadlo R FR Kang Sumin S Chen Jing J
Molecular cell 20111201 6
Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. Myc and HIF-1 are believed to promote such a metabolic switch by, in part, upregulating gene expression of pyruvate dehydrogenase (PDH) kinase 1 (PDHK1), which phosphorylates and inactivates mitochondrial PDH and consequently pyruvate dehydrogenase complex (PDC). Here we report that tyrosine phosphorylation enhances PDHK1 kinase activity by promoting ATP and PDC bindin ...[more]