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Divergent synthetic approach to 6''-modified ?-GalCer analogues.

ABSTRACT: A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6''-modified KRN7000 analogues.

SUBMITTER: Pauwels N

PROVIDER: S-EPMC3246390 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Divergent synthetic approach to 6''-modified α-GalCer analogues.

Pauwels Nora N Aspeslagh Sandrine S Vanhoenacker Gerd G Sandra Koen K Yu Esther D ED Zajonc Dirk M DM Elewaut Dirk D Linclau Bruno B Van Calenbergh Serge S

Organic & biomolecular chemistry 20111101 24

A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6''-modified KRN7000 analogues. ...[more]

PMID: 22042483

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