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Development of ?-GalCer Analogues with an ?-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d.

ABSTRACT: A series of ?-GalCer analogues containing an ?-fluorocarbonyl moiety at the terminal position of the acyl chain were designed for targeting polar residues in the hydrophobic cavity of CD1d using a structure-based approach. The acyl chain length was efficiently adjusted by an asymmetric alkyne-alkyne cross coupling strategy, and the newly synthesized ?-GalCer analogues showed the high Th2-selective activity of iNKT cells. The biased activity of ligands could be caused by the hydrogen-bonding interaction between ligands and CD1d according to the Th2-selective cytokine secretion and molecular docking studies.

SUBMITTER: Kim H

PROVIDER: S-EPMC6511957 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Development of α-GalCer Analogues with an α-Fluorocarbonyl Moiety as Th2-Selective Ligands of CD1d.

Kim Hyunsoo H Song Heebum H Park Jun-Gyu JG Lee Dong-Sup DS Park Seung Bum SB

ACS medicinal chemistry letters 20190424 5

A series of α-GalCer analogues containing an α-fluorocarbonyl moiety at the terminal position of the acyl chain were designed for targeting polar residues in the hydrophobic cavity of CD1d using a structure-based approach. The acyl chain length was efficiently adjusted by an asymmetric alkyne-alkyne cross coupling strategy, and the newly synthesized α-GalCer analogues showed the high Th2-selective activity of iNKT cells. The biased activity of ligands could be caused by the hydrogen-bonding inte ...[more]

PMID: 31097998

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