Ontology highlight
ABSTRACT:
SUBMITTER: Lelli KM
PROVIDER: S-EPMC3248519 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Lelli Katherine M KM Noro Barbara B Mann Richard S RS
Proceedings of the National Academy of Sciences of the United States of America 20111212 52
Homeotic selector (Hox) proteins often bind DNA cooperatively with cofactors such as Extradenticle (Exd) and Homothorax (Hth) to achieve functional specificity in vivo. Previous studies identified the Hox YPWM motif as an important Exd interaction motif. Using a comparative approach, we characterize the contribution of this and additional conserved sequence motifs to the regulation of specific target genes for three Drosophila Hox proteins. We find that Sex combs reduced (Scr) uses a simple inte ...[more]