Ontology highlight
ABSTRACT:
SUBMITTER: Ma L
PROVIDER: S-EPMC4905478 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ma Lin L Zeng Jiping J Guo Qing Q Liang Xiuming X Shen Li L Li Shuyan S Sun Yundong Y Li Wenjuan W Liu Shili S Yu Han H Chen Chunyan C Jia Jihui J
Oncotarget 20160301 10
Helicobacter pylori (Hp) is an environmental inducer of gastritis and gastric cancer (GC). The immune response to Hp and the associated changes in somatic gene expression are key determinants governing the transition from gastritis to GC. We show that hepatocyte nuclear factor 4α (HNF4α) is upregulated by Hp infection via NF-κB signaling and that its protein and mRNA levels are elevated in GC. HNF4α in turn stimulates expression of interleukin-1 receptor 1(IL-1R1), which amplifies the inflammato ...[more]