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Synthesis of (-)-julocrotine and a diversity oriented Ugi-approach to analogues and probes.

ABSTRACT: An improved total synthesis of (-)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (-)-julocrotine analogues was synthesized by employing the heterocyclic precursor as an amino input in Ugi four-component reactions (Ugi-4CR) [1].

SUBMITTER: Neves Filho RA

PROVIDER: S-EPMC3252850 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Synthesis of (-)-julocrotine and a diversity oriented Ugi-approach to analogues and probes.

Neves Filho Ricardo A W RA Westermann Bernhard B Wessjohann Ludger A LA

Beilstein journal of organic chemistry 20111107

An improved total synthesis of (-)-julocrotine in three steps from Cbz-glutamine, in 51% overall yield, is presented. To demonstrate the potential of the heterocyclic moiety for diversity oriented synthesis, a series of (-)-julocrotine analogues was synthesized by employing the heterocyclic precursor as an amino input in Ugi four-component reactions (Ugi-4CR) [1]. ...[more]

PMID: 22238524

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