Unveiling the Link Between Inflammation and Adaptive Immunity in Breast Cancer.

ABSTRACT: Inflammation has been recognized as an important driver in the development and growth of malignancies. Inflammatory signaling in cancer emerges from the combinatorial interaction of several deregulated pathways. Pathway deregulation is often driven by changes in the underlying gene regulatory networks. Confronted with such complex scenario, it can be argued that a closer analysis of the structure of such regulatory networks will shed some light on how gene deregulation led to sustained inflammation in cancer. Here, we inferred an inflammation-associated gene regulatory network from 641 breast cancer and 78 healthy samples. A modular structure analysis of the regulatory network was carried out, revealing a hierarchical modular structure. Modules show significant overrepresentation score

SUBMITTER: Velazquez-Caldelas TE 

PROVIDER: S-EPMC6362261 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature